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Group IIe Group IIa rabbits allowed a normal diet for a further period of 6 Group IId Animals of group IIa transferred to a normal diet and each administered a daily dose of 50 mg of APS/from the 7th to the 12th month. Group IIc Group IIa animals each given 50 mg/day of APS powder (mixed inĬarrot slices) along with 100 mg of cholesterol in the diet from the 7th Group IIb Group IIa animals maintained on a 0.1% cholesterol diet for a further Mg/dl killed at the end of the 6-month experimental period. Group IIa Atherosclerotic animals at a plasma cholesterol level of 900-l 100 These animals formed the members of group II.Īfter 6 months on the cholesterol-supplemented

Plasma cholesterol (checked weekly) was maintained between 900-l 100 mg/dl. Dietary cholesterol was thereafter reduced to 100 mg/day, and the This wasĬontinued for 3 months, by which time plasma cholesterol levels had reachedĩOO- 1100 mg/dl. In with carrot slices) every morning prior to the usual rabbit feed. Group I the control remained healthy throughout the experimental periodĪnd consumed about 100 g of rabbit pellets and 25 g of fresh carrots per day.Īnimals were rendered atherosclerotic by feeding them 0.5 g of cholesterol (mixed They were fed a standard rabbit feed supplied by Hindustan Lever Ltd.,īombay, and water was given ad libitum. Lipids and the possible effect of the drug on the synthesis of lipids from acetateĭuring the progression and regression of atherosclerosis in the rabbit.Ĥ-month-old albino rabbits of both sexes and of 0.9-1.0 kg initial body weight The present investigation concerns the effect of APS on plasma and aortic Sindhooram (APS), was found to exhibit hypolipidemic activity in hypercholesterolemic rats, hypercholesterolemic rabbits and in normal human volunteers Vessels has been well documented [ 12-141. System of Indian medicine in alleviating diseases of the liver, spleen and blood Incomplete burning of iron minerals) and ‘baspam’ (ash of the above) in the Sidha The use of iron-containing ‘sindhooram’ (a reddish brown residue obtained by Īnd Adams and Morgan have indicated a potential for regression of rabbit Lipids of the atherosclerotic rabbit tend to increase [4-71 to a substantial degree evenĢ years after stopping the cholesterol diet, and, in some cases, there is littleĬhange after a l-year regression period. The reversibility of atheroma in man and experi mental animals has attractedĬonsiderable attention but results have been contradictory. Lipid do not culminate in decreased morbidity and mortality from cardiovascular Therapeutic manoeuvres aimed at ridding the artery of Mechanism of lipid deposition, reports concerning the regression ofĪtherosclerosis are very few. Despite the availability of a large body of information regarding the The results indicate that APS may play anĪnti-atherogenic role if used in larger doses.Īccumulation of lipid in the arterial wall plays a crucial role in the genesis ofĪtherosclerosis and has been the subject of extensive u-rvestigqtion since the time ofĪnitschkow [ 11. injection.ĪPS was found to be hypolipidemic and induced partial regression of rabbitĪtheroma and decreased lipogenesis. Synthesis of lipids using acetate as a precursor was studied after i.v. The animals were killed, and their plasma and aortic lipid components estimated.Ītherosclerotic lesions of the aorta were quantified and examined histologically. TheseĪnimals were then divided into six groups and given 50 mg of APSįor a further 6 months.

Rabbits wereįed a cholesterol rich (0.5%) diet for 6 months to induce atherosclerosis. Sidha formulation was investigated on experimental atherosclerosis. The effect of orally administered Anna Pavala Sindhooram (APS), a herbo-mineral Effect of Anna Pavala Sindhooram on Plasma andĪortic Lipids in Experimental Atherosclerosisĭepartment of Biochemistry, PostGraduate Institute of Basic Medical Sciences, University of Madras,